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1

A Phase I Study of an Adeno-Associated Virus-CFTR Gene Vector in Adult CF Patients with Mild Lung Disease. Johns Hopkins Children's Center, Baltimore, Maryland

Flotte, Terence, Carter, Barrie, Conrad, Carol, Guggino, William, Reynolds, Thomas, Rosenstein, Beryl, Taylor, George, Walden, Sandra, Wetzel, Randall

Journal:

Human Gene Therapy

Year:

1996

Language:

english

File:

PDF, 1.20 MB

english, 1996

2

1α,25-Dihydroxyvitamin D3 Hybrid Analogs with Structural changes at both the A-ring and the C,D-ring side-chain. II

Gary H. Posner, Jae Kyoo Lee, Zhengong Li, Kazuhiro Takeuchi, Sandra E. Guggino, Patrick Dolan, Thomas W. Kensler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 297 KB

english, 1995

3

Total synthesis of 25-Hydroxy-16,23E-diene Vitamin D3 and 1α,25-Dihydroxy-16,23E-diene Vitamin D3: separation of genomic and nongenomic vitamin D Activities

Marek M. Kabat, Walter Burger, Sandra Guggino, Bernard Hennessy, Jerome A. Iacobelli, Kazuhiro Takeuchi, Milan R. Uskokovic

Journal:

Bioorganic & Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 212 KB

english, 1998

4

Tubular and cellular localization of the cardiac L-type calcium channel in rat kidney

Zhao, Pei-Lin, Wang, Xi-Tao, Zhang, Xue-Mei, Cebotaru, Valeriu, Cebotaru, Liudmila, Guo, Gang, Morales, Marcelo, Guggino, Sandra E.

Journal:

Kidney International

Year:

2002

Language:

english

File:

PDF, 8.18 MB

english, 2002

5

Turgor regulation inValonia macrophysafollowing acute osmotic shock

Sandra Guggino, John Gutknecht

Journal:

Journal of Membrane Biology

Year:

1982

Language:

english

File:

PDF, 1.32 MB

english, 1982

6

Ca2+-activated K+channels from cultured renal medullary thick ascending limb cells: Effects of pH

Miguel Cornejo, Sandra E. Guggino, William B. Guggino

Journal:

Journal of Membrane Biology

Year:

1989

Language:

english

File:

PDF, 564 KB

english, 1989

7

Neurotransmitter regulation of cytosolic calcium in osteoblast-like bone cells

Hiromichi Kumagai, Hisato Sakamoto, Sandra Guggino, Charles R. Filburn, Bertram Sacktor

Journal:

Calcified Tissue International

Year:

1989

Language:

english

File:

PDF, 311 KB

english, 1989

8

Estrogen modulates ClC-2 chloride channel gene expression in rat kidney

Danielle S. Nascimento, Carlos U. Reis, Regina C. Goldenberg, Tânia M. Ortiga-Carvalho, Carmen C. Pazos-Moura, Sandra E. Guggino, William B. Guggino, Marcelo M. Morales

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2003

Language:

english

File:

PDF, 293 KB

english, 2003

9

Characterization of endogenous betaine γ-amino-n-butyric acid cotransporter glycoform and its hyperosmotic regulation in MDCK cells

Xue-Mei Zhang, Xi-Tao Wang, Hui Cai, Steve W. Leung, Sandra E. Guggino

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2007

Language:

english

File:

PDF, 1.14 MB

english, 2007

10

L-type calcium channel activity in osteoblast cells is regulated by the actin cytoskeleton independent of protein trafficking

Fangping Li, Wenwei Wang, Ming Gu, Stefka Gyoneva, Jie Zhang, Shiying Huang, Stephen F. Traynelis, Hui Cai, Sandra E. Guggino, Xuemei Zhang

Journal:

Journal of Bone and Mineral Metabolism

Year:

2011

Language:

english

File:

PDF, 413 KB

english, 2011

11

1α,25-dihydroxyvitamin D3 hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain

Gary H. Posner, M.Christina White, Patrick Dolan, Thomas W. Kensler, Shigefumi Yukihiro, Sandra E. Guggino

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 513 KB

english, 1994

12

High citrate diet delays progression of renal insufficiency in the ClC-5 knockout mouse model of Dent's disease

CEBOTARU, VALERIU, KAUL, SADHANA, DEVUYST, OLIVIER, CAI, HUI, RACUSEN, LORRAINE, B GUGGINO, WILLIAM, E GUGGINO, SANDRA

Journal:

Kidney International

Year:

2005

Language:

english

File:

PDF, 231 KB

english, 2005

13

A New Insight into Pathophysiological Mechanisms of Zinc in Diarrhea

Kazi Mirajul Hoque, Rafiquel Sarker, Sandra E. Guggino, Chung-Ming Tse

Journal:

Annals of the New York Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 215 KB

english, 2009

14

Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR

Egan, Marie, Flotte, Terence, Afione, Sandra, Solow, Rikki, Zeitlin, Pamela L., Carter, Barrie J., Guggino, William B.

Journal:

Year:

1992

File:

PDF, 469 KB

1992

15

Renal anion transport

Guggino, William B, Guggino, Sandra E

Journal:

Kidney International

Year:

1989

Language:

english

File:

PDF, 752 KB

english, 1989

16

The renal cGMP-gated cation channel: Its molecular structure and physiological role

McCoy, David E, Guggino, Sandra E, Stanton, Bruce A

Journal:

Kidney International

Year:

1995

Language:

english

File:

PDF, 982 KB

english, 1995

17

Can we generate new hypotheses about Dent's disease from gene analysis of a mouse model?

Sandra E. Guggino

Journal:

Experimental Physiology

Year:

2009

Language:

english

File:

PDF, 616 KB

english, 2009

18

Cardiac L-Type Calcium Channel α1-Subunit Is Increased by Cyclic Adenosine Monophosphate: Messenger RNA and Protein Expression in Intact Bone

Xi-Tao Wang, Shizuka Nagaba, Yasushi Nagaba, Steven W. Leung, Jinsong Wang, Weiping Qiu, Pei-Lin Zhao, Sandra E. Guggino

Journal:

Journal of Bone and Mineral Research

Year:

2000

Language:

english

File:

PDF, 2.65 MB

english, 2000

19

The ClC-5 Knockout Mouse Model of Dent's Disease Has Renal Hypercalciuria and Increased Bone Turnover

Ian V Silva, Valeriu Cebotaru, Hua Wang, Xi-Tao Wang, Sha Sha Wang, Gang Guo, Olivier Devuyst, Rajesh V Thakker, William B Guggino, Sandra E Guggino

Journal:

Journal of Bone and Mineral Research

Year:

2003

Language:

english

File:

PDF, 1.80 MB

english, 2003

20

Modulation of renal CNG-A3 sodium channel in rats subjected to low- and high-sodium diets

Horacio J. Novaira, Bruno F. Botelho, Regina C. Goldenberg, Sandra E. Guggino, Marcelo M. Morales

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2004

Language:

english

File:

PDF, 602 KB

english, 2004

21

Impaired acidification in early endosomes of ClC-5 deficient proximal tubule

Mariko Hara-Chikuma, Yinghong Wang, Sandra E. Guggino, William B. Guggino, A.S. Verkman

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 447 KB

english, 2005

22

The mRNA of L-Type Calcium Channel Elevated in Colon Cancer: Protein Distribution in Normal and Cancerous Colon

Xi-Tao Wang, Yasushi Nagaba, Heide S. Cross, Fritz Wrba, Lin Zhang, Sandra E. Guggino

Journal:

The American Journal of Pathology

Year:

2000

Language:

english

File:

PDF, 5.10 MB

english, 2000

23

Metabolites and analogs of 1α,25-dihydroxyvitamin D3: evaluation of actions in bone

Sudha Kadiyala, Shizuka Nagaba, Kazuhiro Takeuchi, Shigefume Yukihiro, Weiping Qiu, Sharon T Eyes, Milan R Uskokovic, Gary H Posner, G.Satyanarayana Reddy, Sandra E Guggino

Journal:

Year:

2001

Language:

english

File:

PDF, 231 KB

english, 2001

24

CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

Erik M. Schwiebert, Marie E. Egan, Tae-Ho Hwang, Stephanie B. Fulmer, Sandra S. Allen, Garry R. Cutting, William B. Guggino

Journal:

Year:

1995

Language:

english

File:

PDF, 1.23 MB

english, 1995

25

Evolution of the ΔF508 CFTR mutation

Sandra E Guggino

Journal:

Trends in Microbiology

Year:

1999

Language:

english

File:

PDF, 95 KB

english, 1999

26

983 Clc-5 Knockout Mice Are More Susceptible to Dextran Sulphate Sodium (DSS) Induced Colitis

Philip Alex, Thuan Nguyen, Jennifer Sipes, Liberty Gonzales, Mei Ye, Chaim Golfeiz, Zubin Arora, Ting Zhang, Michael Centola, Sandra E. Guggino, Xuhang Li

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 52 KB

english, 2009

27

Gates of Janus: cystic fibrosis and diarrhea

Guggino, Sandra E.

Journal:

Trends in Microbiology

Year:

1994

Language:

english

File:

PDF, 532 KB

english, 1994

28

Extracellular Acidification Alters Lysosomal Trafficking in Human Breast Cancer Cells

Glunde, Kristine, Guggino, Sandra E., Solaiyappan, Meiyappan, Pathak, Arvind P., Ichikawa, Yoshitaka, Bhujwalla, Zaver M.

Journal:

Year:

2003

Language:

english

File:

PDF, 955 KB

english, 2003

29

mRNA expression of L-type calcium channels increases in colon cancer

Nagaba, Yasushi, Zhang, Lin, Vogelstein, Bert, Cross, Heide, Guggino, Sandra

Journal:

Gastroenterology

Year:

1998

Language:

english

File:

PDF, 129 KB

english, 1998

30

W1661 Reduced Stimulation of NHE3 Activity and Reduced Exocytosis with Knockdown of Clc-5, An Endosomal Chloride Channel

Lin, Zhihong, Kovbasnjuk, Olga, Murtazina, Rakhilya, Cha, Boyoung, Zachos, Nicholas C., Hubbard, Ann, Donowitz, Mark, Guggino, Sandra E.

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 51 KB

english, 2009

31

Bone Remodeling Signaled by a Dihydropyridine- and Phenylalkylamine-Sensitive Calcium Channel

Sandra E. Guggino, Daniel Lajeunesse, John A. Wagner and Solomon H. Snyder

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 864 KB

english, 1989

32

1.alpha.,25-Dihydroxyvitamin D3 Analogs Featuring Aromatic and Heteroaromatic Rings: Design, Synthesis, and Preliminary Biological Testing

Posner, Gary H., Li, Zhengong, White, M. Christina, Vinader, Victoria, Takeuchi, Kazuhiro, Guggino, Sandra E., Dolan, Patrick, Kensler, Thomas W.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.21 MB

english, 1995

33

Absence of ClC5 in Knockout Mice Leads to Glycosuria, Impaired Renal Glucose Handling and Low Proximal Tubule GLUT2 Protein Expression

Souza-Menezes, Jackson, Morales, Marcelo, Tukaye, Deepali, Guggino, Sandra, Guggino, William

Journal:

Cellular Physiology and Biochemistry

Year:

2007

Language:

english

File:

PDF, 419 KB

english, 2007

34

Expression of a Truncated Cystic Fibrosis Transmembrane Conductance Regulator with an AAV5-pseudotyped Vector in Primates

Fischer, Anne C, Smith, Carolina I, Cebotaru, Liudmila, Zhang, Xuemei, Askin, Frederic B, Wright, Jerry, Guggino, Sandra E, Adams, Robert J, Flotte, Terence, Guggino, William B

Journal:

Molecular Therapy

Year:

2007

Language:

english

File:

PDF, 400 KB

english, 2007

35

The Loss of the Chloride Channel, ClC-5, Delays Apical Iodide Efflux and Induces a Euthyroid Goiter in the Mouse Thyroid Gland

van den Hove, Marie-France, Croizet-Berger, Karine, Jouret, François, Guggino, Sandra E., Guggino, William B., Devuyst, Olivier, Courtoy, Pierre J.

Journal:

Year:

2006

Language:

english

File:

PDF, 374 KB

english, 2006

36

Mechanisms of Disease: what can mouse models tell us about the molecular processes underlying Dent disease?

Guggino, Sandra E

Journal:

Nature Clinical Practice Nephrology

Year:

2007

Language:

english

File:

PDF, 312 KB

english, 2007

37

Direct Modulation of Secretory Chloride Channels by Arachidonic and Other Cis Unsaturated Fatty Acids

Tzyh-Chang Hwang, Sandra E. Guggino and William B. Guggino

Journal:

Proceedings of the National Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 812 KB

english, 1990

38

Stable in vivo Expression of the Cystic Fibrosis Transmembrane Conductance Regulator with an Adeno-Associated Virus Vector

Terence R. Flotte, Sandra A. Afione, Carol Conrad, Sharon A. McGarth, Rikki Solow, Hidemi Oka, Pamela L. Zeitlin, William B. Guggino and Barrie J. Carter

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.70 MB

english, 1993

39

Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteins

Wright, Jerry M., Zeitlin, Pamela L., Cebotaru, Liudmila, Guggino, Sandra E., Guggino, William B.

Journal:

Physiological Genomics

Year:

2004

Language:

english

File:

PDF, 206 KB

english, 2004

40

[Current Topics in Membranes] Amiloride-Sensitive Sodium Channels - Physiology and Functional Diversity Volume 47 || Chapter 16 Cyclic Nucleotide-Gated Cation Channels Contribute to Sodium Absorption in Lung: Role of Nonselective Cation Channels

Guggino, Sandra

Year:

1999

Language:

english

File:

PDF, 1.49 MB

english, 1999

41

Heat-Stable Toxin from Escherichia coli Activates Chloride Current via cGMP-Dependent Protein Kinase

Lin, Meiqiu, MacLeod, Katrina, Guggino, Sandra

Journal:

Cellular Physiology and Biochemistry

Year:

1995

Language:

english

File:

PDF, 1.48 MB

english, 1995

42

Delayed Expression of Adeno-Associated Virus Vector DNA

Afione, Sandra A., Wang, Jianming, Walsh, Scott, Guggino, William B., Flotte, Terence R.

Journal:

Year:

1999

Language:

english

File:

PDF, 761 KB

english, 1999

43

pH-regulated chloride secretion in fetal lung epithelia

Blaisdell, Carol J., Edmonds, Rebecca D., Wang, Xi-Tao, Guggino, Sandra, Zeitlin, Pamela L.

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2000

File:

PDF, 428 KB

2000

44

Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats

Norlin, Andreas, Lu, Le Nha, Guggino, Sandra E., Matthay, Michael A., Folkesson, Hans G.

Journal:

Journal of Applied Physiology

Year:

2001

File:

PDF, 182 KB

2001

45

pH-regulated chloride secretion in fetal lung epithelia

Blaisdell, Carol J., Edmonds, Rebecca D., Wang, Xi-Tao, Guggino, Sandra, Zeitlin, Pamela L.

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2000

Language:

english

File:

PDF, 428 KB

english, 2000

46

Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats

Norlin, Andreas, Lu, Le Nha, Guggino, Sandra E., Matthay, Michael A., Folkesson, Hans G.

Journal:

Journal of Applied Physiology

Year:

2001

Language:

english

File:

PDF, 182 KB

english, 2001

47

A Novel Method of Imaging Lysosomes in Living Human Mammary Epithelial Cells

Glunde, Kristine, Guggino, Sandra E., Ichikawa, Yoshitaka, Bhujwalla, Zaver M.

Journal:

Molecular Imaging

Year:

2003

Language:

english

File:

PDF, 725 KB

english, 2003

48

PTH regulates expression of ClC-5 chloride channel in the kidney

Silva, Ian V., Blaisdell, Carol J., Guggino, Sandra E., Guggino, William B.

Journal:

American journal of physiology. Renal physiology

Year:

2000

File:

PDF, 216 KB

2000

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